Acomplia(
Generic Acomplia)
Company: Sanofi-Aventis
Acomplia is the most eficient weight loss drug. It was
approved for marketing in the European Union in June 2006. It
has been granted market authorization in 40 countries and is sold
within 20 of them throughout the world
What is
Acomplia?
" Acomplia
(rimonabant) is the first in a new class of therapeutic agents
called Cannabinoid-1 Receptor Blockers (CB1).
" Acomplia is succesufully used to help the heavily overweight
reach a healthy weight level
How does
Acomplia work?
" Acomplia
works by selectively blocking CB1 receptors found in the brain
and in peripheral organs important in glucose and lipid metabolism,
including adipose tissue, the liver, gastrointestinal tract and
muscle.
" Acomplia switches off the same brain circuits that make
people hungry when they smoke cannabis.
" CB1 receptor blockade with Acomplia acts to decrease the
overactivity of the endocannabinoid system (EC system). The EC
system is a recently characterised physiological system that includes
receptors such as the CB1 receptor and it has been shown to play
an important role in regulating body weight and in controlling
energy balance, as well as glucose and lipid (or fat) metabolism.
What is
Generic Acomplia used for?
" Generic
Acomplia is helping combat the world's rising levels of obesity.
Acomplia is used complementary to diet and exercise to treat heavily
overweight patients who suffer from Type 2 diabetes and abnormal
levels of fat in the blood. Is used in conjunction with low calorie
diet and regular exercise
" The company who invented Generic Acomplia argues that this
amazing drug can also prevent the risk of cardiovascular disease
and also aid smokers quit smoking.
" Patients with large waist circumference (defined as 102
cm/ 40 inches in men and 88 cm/ 35 inches in women) will mostly
benefit from taking this revolutionary medication.
" Acomplia also showed a high rate of psychiatric side effects,
notably depression and anxiety, the study found
Does Acomplia
really aid smokers
" Acomplia
has been studied by sanofi-aventis as an aid to smoking cessation
based on studies for up to one year in over 6,500 smokers who
wanted to quit smoking.
" Sanofi-aventis submitted a New Medication Application to
the FDA, which in turn issued a non approvable letter for Acomplia
for use in smoking cessation. An approvable letter was however
issued for Acomplia for use in weight management.
What were
the results of Acomplia Clinical trial studies?
" In
clinical studies, Generic Acomplia has been shown to improve a
wide array of cardiometabolic risk factors as well as promoting
sustained weight loss
" In patient who received Acomplia 20 mg approximately half
of the observed improvement in HDL-cholesterol, triglycerides
and HbA1C (an indicator of blood sugar control) was beyond that
expected from weight loss alone.
Possible
side-effects of Acomplia?
" Side
effects when it is taking Generic Acomplia to treat obesity are
vomiting, dry mouth, anxiety, sleep disorders,irritability and
nausea, forcing about 19 percent of patients to leave the trial
versus 13 percent of those who took placebo.
Recommended
Acomplia dosage
It is Recommended
to take a 20mg Acomplia tablet daily.
Acomplia
Overdose
Experience
with Genric Acomplia overdosage is limited. In cases of overdose
the following symptoms were reported; headache, fatigue and insomnia,
euphoria. If an Acomplia overdose is suspected ensure that airways
are kept clear, monitor heart activity and contact a health profesional
immediately.
Generic
Acomplia should NOT be used in patients:
" Who
are allergic to this medication or any of the inactive ingredients
in Acomplia
" Patients that have a galactose intolerance or glucose-galactose
malabsorption
" Women that are breast feeding. If you become pregnant or
plan to become pregnant whilst taking Acomplia inform your doctor
.
Acomplia
Ingredients:
Active Ingredient:
Rimonabant
Inactive Ingredients: Tablet core: maize starch, lactose monohydrate,
povidone K 30 (E1201), croscarmellose sodium (E468), sodium laurilsulfate
(E487), microcrystalline cellulose (E460), magnesium stearate
Tablet coating: lactose monohydrate, hypromellose 15 mPa.s (E464),
titanium dioxide (E171), macrogol 3000
Tablet polishing: carnauba wax (E903)
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